Natural-product-like chiral derivatives by solid-phase synthesis.
نویسندگان
چکیده
In this genomics and proteomics age, highly functionalized natural products or natural-product-like compounds are likely to play important roles in understanding the functions of emerging biological targets because they serve as small-molecule chemical probes in modulating a target's specific actions (i.e. activation or deactivation). Development of stereoselective reaction-derived methods on solid phase provides a means of obtaining functionalized chiral core structures that may be used for high-throughout syntheses.
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عنوان ژورنال:
- Current opinion in chemical biology
دوره 5 3 شماره
صفحات -
تاریخ انتشار 2001